Is Neuropsychological Development Related to Maternal Hypothyroidism or to Maternal Hypothyroxinemia?

Is neuropsychological development related to maternal hypothyroidism or to maternal hypothyroxinemia?

Several recent publications have drawn attention to the role of the thyroid hormone status of the mother on the future neuropsychological development of the child. The screening of pregnant women for clinical or subclinical hypothyroidism based on second trimester elevated maternal TSH values has been proposed. Here, we have summarized present epidemiological and experimental evidence strongly ...

Maternal hypothyroxinemia: psychoneurological deficits of progeny.

Maternal thyroid function was evaluated clinically, by reproductive history, and by serial measurements of serum butanol-extractable iodine (thyroxine-like iodine), two before and two after 24 gestational weeks during 1,349 pregnancies. Three percent of the women were hypothyroxinemic. Developmental, intellectual, and motor abilities of progeny born to (Group I) 210 euthyroxinemic, (Group II) 1...

Maternal hypothyroidism and child development. A review.

Doubts and Concerns about Isolated Maternal Hypothyroxinemia

There is evidence that isolated maternal hypothyroxinemia may have detrimental effects on both mother and foetus. Nonetheless, this condition is still far from being universally accepted as a separate thyroid disease, and a standard definition of this state of mild thyroid underfunction is still lacking. We will review the biochemical criteria used to define isolated maternal hypothyroxinemia, ...

Maternal Hypothyroidism and Pregnancy

Hypothyroidism during pregnancy poses a challenge to the treating clinician. The diagnosis is made by a TSH that is greater than normal, and during pregnancy, this situation deserves therapy. Research over the years has shown that maternal thyroid hormones are very important in pregnancy. Importantly, emerging data seems to suggest that thyroid hormones are important for fetal brain development...